Investing in Genomics
The science of genomics involves the study of an organism’s genome, effectively its DNA. But genomics is not genetics, it is the study of the complete set of genetic information that makes up an organism, including genes and non-coding DNA. Furthermore, research and development across proteomics, the study of proteins, and metabolomics, the study of small molecules, are creating a “multiomics” opportunity where integrating data from such diverse sources revolutionises the detection and treatment of cancer and other diseases.
Genetics by contrast focuses on heredity, including the function and composition of specific genes. Genomics is more the big picture observation of all the DNA in an organism, both coding and non-coding constituents.
In this guide to investing in Genomics, you will learn about the following:
Why is genomics getting exciting?
By reading, or “sequencing”, the human genome (one’s DNA), scientists are able to detect, predict, and potentially cure the mutations that cause many diseases. Next-generation DNA-sequencing technology is getting better all the time. Sequencing the first human genome was a massive exercise – it took 10 years and cost billions of pounds. Now, the same process can take less than 24 hours and costs less than £1000 depending on the method
The advantage of genomics is that a full study of a human being’s genome (consisting of 3 billion base pairs and 100-200 GB of data) can provide healthcare professionals with a much more complete picture of a human being, not just the hereditary aspects. Genomics is becoming an important part of routine healthcare around the world.
Genomics can now play a critical role in the development of next-generation treatments for human diseases. Recent breakthroughs have included advances in pharmogenomics, using this information to study responses by an individual to specific drugs, and the development of genome editing.
Beyond healthcare, genomics is pushing back the frontiers in other areas of science, for example in agriculture, where it is being used to improve crops, livestock and other agricultural products. It is also being used in forensics to deliver more insights into evidence left at crime scenes.
In the wake of the Covid pandemic, however, genomics also stands to provide mankind with its next line of defence in the early identification and treatment of the pandemics of the future.
Forecast growth for the genomics sector
Genomics is considered to be a major area of growth within the healthcare and wider scientific sectors over the next 20 years. Overall forecasts vary, but the numbers look great. Over the next five years the sector is anticipated to grow by 12.4% CAGR from its 2023 size of $46.2bn, to a level of at least $80bn, according to research from Markets & Markets.
Longer term forecasts see even more stellar growth. SkyQuest Technology estimates the sector could be worth around $411bn by 2031. Indeed, ARK Invest has forecasted that the genomics innovation platforms will scale at nearly a 40% CAGR through the end of this decade.[1]
Bear in mind the sector also benefits from considerable government grants all over the planet. The increasing incidence of cancer globally, for example, is prompting further public investment into genomics projects. There is a stress on finding simple and effective cancer diagnosis, for example.
[1] Source: ARK Invest Big Ideas 2024 publication (page 13).
Functional genomics dominates
The genomics sector is still dominated by the functional genomics sector, which accounts for around 32% of revenues. This is where a lot of the research is currently being carried out into cancer gene therapies.
Cutting edge work in Europe into CRISPR/Cas9-based functional genomics screens at the single cell level is one example of this. Analysts estimate functional genomics will continue to see the highest growth potential within the genomics sector between now and 2031.
Genomics is also playing a more important role in the development of drugs. Many companies are now using the technology as part of their drugs trials, as it can deliver a much higher level of precision in their results. With the cost of genomic sequencing dropping rapidly, the tech can also now be rolled out at the hospital and clinic level. It can help with detecting unrecognised and scarce disorders in patients.
It comes as no surprise to see that North America dominates the genomics market. Estimates vary, but the region dominates the global genomics market to the tune of at least 42%. This is thanks in no small part to the amount of money being poured into research by US pharma groups and heavily funded research organisations.
However, the Asia-Pacific region is expected to start closing the gap in genomics over the next five years. Healthcare providers in Asia are expected to roll out more genomics-based screening and therapy procedures over the next few years, and there are also some larger projects underway, like the massive Genome Asia 100K project, which is analysing 100,000 genomes within the region. This could also lead to the development of drugs specifically targeted at Asian genomes.
It all sounds very exciting. Investors should be aware that the sector does face some headwinds as well. The rapid expansion of the market means there are not enough educated genomics professionals to fill all the jobs it is creating. This could turn into a real drag on the sector.
The other issue relates to data integration challenges. Genomics is very data intensive: a single patient exam can create a terabyte of data but can mushroom well beyond that once you factor in all the subsequent procedures. As more patients fall into the scope of gene-based treatments, the amount of patient data processed will mushroom massively. Are on the ground healthcare operations going to have the required data infrastructure to meet this challenge?
Investing in the genomics market
There are a number of different routes towards investing in the growth of the genomics sector. Exchange-Traded Funds (“ETFs”) are a great place to start as there are now specialist genomics and biotech ETFs which are also laser-focused on the sector. The advantage of these is that they can capture a lot of the long-term growth across the genomics industry, without the risk of investing in single stocks. Furthermore, some of these strategies may deploy researchers with domain expertise to assist in stock selection, such as Doctorates in associated genomics fields.
For those who are meaningfully more risk tolerant, individual stock picking remains an option. Some safer (but severely more diluted) options include the healthcare giants which will have exposure to the sector, largely because they are helping to fund ongoing R&D and deploying the technology in the marketplace.
Private equity and venture capital funds are also very active in the space, but they have the disadvantage of requiring a great deal of capital be committed up front, and in most cases lock up capital for five or more years.
Investing in Genomics with Exchange Traded Funds
Adding a genomics themed ETF to your portfolio can provide you with the genomics and biotech exposure you are looking for without the risk of relying on a single stock for investment returns (see below). A genomics-themed ETF will consist of a number of genomics related stocks, chosen by the manager in accordance with the ETF’s objectives. This may be a focus on smaller companies, or larger, more established businesses. Some funds may track a benchmark, while others may be active and benchmark-agnostic in their stock selection based on their research and forward-looking convictions. Make sure you research the objectives of each genomics ETF before you purchase to ensure the exposure you will gain meets with your investment goals.
Here are some genomics ETFs for you to consider. These ETFs can be purchased via most established online platforms. We have a selection of investment platforms to help you get started – listed below.
Genomic Revolution UCITS ETF | Genomics LON:ARKG / USD | |
BioRevolution UCITS ETF | Genomics LON:WDNA / USD | |
Investing in Genomics stocks & shares
Investors can gain exposure to the genomics megatrend by investing in listed companies that are focused on bio- and healthcare tech. Some companies in the sector include the likes of Illumina NASDAQ:ILMN and/or Pacific Biosciences of California NASDAQ:PACB for gene sequencing, CRISPR Therapeutics AG NASDAQ:CRSP for gene editing, and/or companies like Recursion Pharmaceuticals NASDAQ:RXRX that focus on the intersection of Artificial Intelligence and genomics for drug discovery. Smaller business that are positioned within the sector can also offer more significant rewards, but they will come with far more risk.
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Abingdon Health had seen its stock price struggle following IPO and wrangles with government, but now it is booming.
BioNtech shares double as experts warn of Covid vaccine escape variant
Panel of experts tells Third Bridge that mRNA is best bet in case a Covid variant emerges that bypasses the vaccine.
Podcast: First half markets review and end of Season 1
It's the end of our first season of podcasts and time for summer holidays, so we take the opportunity to go back over the last six months.
Avacta shares: one shot pony or more to come from AIM biotech stock?
For Members Only: a close look at AIM-listed Avacta (LSE:AVCT) and both their COVID-19 lateral flow test and new cancer therapies
NeuroMetrix stock: should investors sit tight after big fall?
NeuroMetrix stock saw major gyrations this month, but the question is whether it is still worth backing for the long term?
Rritual Superfoods’ growth strategy is reaping dividends
Rritual Superfoods has set itself new distribution targets this year having already exceeded its original 10,000 outlet goal.
EnWave Corp in deal with AstraZeneca affiliate for antibody dehydration
EnWave Corporation has a proof of concept trial with AstraZeneca affiliate to see if its technology can assist with faster drying of antibodies
Rritual Superfoods confirms new product line for autumn
Innovation continues as adaptogens specialist announces it will be adding new skin and hair health product to existing range.
Faron Pharmaceuticals: can this AIM-listed Finnish biotech rise to the COVID challenge?
Our Nordic correspondent Raine Lahtinen takes a closer look at AIM-listed Finnish biotech company Faron Pharmaceuticals.
ValiRx: is share price still justified given new team and market cap discrepancy?
We take a closer look at oncology drug developer ValiRx as a new CEO arrvies: is this company looking way too cheap versus its peers?
GlaxoSmithKline: what do institutional investors think of struggling pharma stock?
We run the Irithmics artificial intelligence rule over GlaxoSmithKline shares to find out what long term and short term funds are thinking.
DeepVerge sees share price on the move with demand for Covid water testing
We take a look at AIM-listed DeepVerge, a company that is attracting investor interest thanks to its work looking for Covid in waste water
Seasonal trends to monitor as we head into the summer months
Giles Coghlan, Chief Currency Analyst at HYCM, explores whether there is any truth to the saying 'sell in May and go away.'
Biogen shares: rough week as debate rages over Alzheimer drug
Controversy over the speed of approval of Biogen's Alzheimer's treatment is causing some investors to take profits.
Clover Health: can this meme stock ever live up to the hype?
Can this meme stock really go to the moon, is it a short term short squeeze, or has it seen its day already?
Rritual Superfoods confirms strong sales figures, European negotiations
Mushroom-based health foods specialist confirms growing purchase orders, in talks with major European distributors including Superdrug.
Netscientific: AIM-listed life sciences and sustainability investor getting more attention
NetScientific is getting attention thanks to its ProAxsis stake and encouraging progress by its portfolio company PDS Biotechnology
Rritual Superfoods hits 2021 retail distribution targets six months early
Rritual Superfoods confirms that its products are now available in 2400 retail locations and 10,000 points of distribution
Sareum Holdings reports delays in auto-immune research, but “encouraging” results
Sareum Holdings sees delays in its auto-immune research but progress on treatment for COVID 19 lung inflammation treatment on schedule
Rritual Superfoods in compostable products tie up with NEXE Technologies
Rritual Superfoods and NEXE are going to work on the development of compostable packaging and a new range of drinks.
Rritual Superfoods launches its Canadian distribution strategy for elite health foods
Rritual Superfoods is teaming up with health foods specialist Ultimate Sales Canada to support roll out of its natural health brands
Synairgen: investors anxiously waiting for Phase III trial results
Investors in the shares of COVID treatment developer Synairgen are waiting on phase III trial results, but it looks positive to us.
Precipio stock: why investors should be cautious on this COVID testing phenomena
Precipio stock bounded upwards when it announced a deal with Amazon, but investors expecting sustained growth need to be cautious.
Novacyt share price drop: time to get out or buying opportunity?
Novacyt is debt free and building a globally diversified revenue base but shares have tumbled with the loss of major UK governement contract
Avacta Group: can this share build on Covid mutation testing success?
Avacta is cautious about being able to repeat its stellar share price performance of 2020, but its results speak for themselves.
Podcast: Q&A with Ailsa Craig of the International Biotechnology Trust
For this Podcast, we speak with Ailsa Craig of International Biotechnology Trust which concentrates its activity in the biotech sector
Apollon Formularies goes live on Aquis Exchange via reverse takeover
Jamaica-based specialist in cutting edge THC R&D for patients is building the foundations for international expansion.
HempFusion products complete anti-inflammatory medicine trial in US
HempFusion's CBD capsules have been used for a landmark study on the effects of cannabidiol on inflammation, a key area of research for pain relief.
DiaSorin shares: poised for recovery as non-COVID testing businesses come back online
While investors are disappointed with its recent dividend, there is more evidence that DiaSorin's non-Covid business lines are coming back to life.
Futura Medical shares up over 250% YTD: is there more to come?
Futura Medical shares have been soaring on the back of EU distribution prospects, but we think there could be more developments to come.
Market waits on detail of new Creso Pharma (ASX:CPH) capital raise
Shares in Creso Pharma have temporarily stopped trading as the company puts together a financing package following announcement of Halucenex deal.
Open Orphan: My pick for this year’s ISA allowance
Master Investor Editor in Chief James Faulkner reveals his top pick, Open Orphan, for this year’s ISA allowance as the tax year draws to a close
Rritual Superfoods lists on Frankfurt Stock Exchange
We anticipated demand for Rritual Superfoods stock when it first came to the market - now the company is listing shares in Germany too.
Vaccine roll out has pushed the life sciences sector to centre stage
As millions more people receive vaccines against COVID, some fund managers are comparing life sciences with Big Oil in terms of its future importance.
Up for sale: Renishaw Group well-positioned to find the right match
Renishaw Group has a unique culture and a range of products that will only increase in demand. It looks to be in good shape for its new owner
Braveheart Investment Group on track for Covid-19 rapid test
Braveheart is not a one trick pony and is already earning the love of investors with some spectacular dividend pay outs from its successful disposals.
World Nano Foundation calls for more investment into pandemic prevention technologies
There is likely to be huge investment by governments and corporates in pandemic prevention in the years to come but which areas should they focus on?
Is Omega Diagnostics’ share price turning a corner?
Omega Diagnostics shares are up 36% in a month following selection by the UK government as one of three UK companies to work on a vital rapid COVID-19 test
Kanabo shares: Is successful listing the start of a new wave of London cannabis opportunities?
The recent success of new cannabis listings in London demonstrate strong investor appetite, but stocks need to be clear on their focus.
Ocugen stock: is this COVID-19 vaccine play simply too risky?
Ocugen has seen its share price fly on the back of hopes that it can get an Indian Covid vaccine through the US regulatory approvals process.
Scancell Holdings seeing heavy buying today as it continues quest for COVID vaccine
Scancell Holdings saw its share price rocket today on news that it is working to deploy a vaccine to cope with a range of mutations in 2022.
Why the COVID-19 diagnostics sector still has legs: finnCap research
Over £1 billion was raised by life sciences companies on AIM last year, driven by massive demands for new virus diagnostics technologies, says finnCap.
Senseonics Holdings (NYSE:SENS) is on a roll, but what is driving the share price?
Senseonics has seen volumes and its share price spike +230% in the last few days as it has signed a major new deal with a healthcare provider.
HempFusion Wellness receives USDA approval for CBD tinctures
CBD wellness specialist HempFusion is up already following its IPO on 6 January and has now reported further USDA Organic certifications for its products.
Tiziana Life Sciences share price perks up in the lead up to LSE listing
Biotech specialist has already created plenty of excitement among investors with its work in the area of nasal sprays for coronavirus treatment.
Are Moderna shares a safe bet for investors?
Moderna is widely expected to win regulatory approval and mega bucks for its Covid-19 vaccine that could help put an end to the global pandemic. But this stock is not for the faint hearted
Cannabis stocks poised for second wave on US and UN legislation
Recent legislative moves in Congress and the UN seem to be paving the way for a boom year in 2021 for the cannabis sector.
Pfizer spinoff opens way to revenue growth
We take a look at the prospects for drug giant Pfizer as it nears the finishing post to roll out a vaccine for the coronavirus.
Omega Diagnostics shares drop as major investor pulls out
Omega Diagnostics' stock is slipping as its tests come under fire in the British Medical Journal and a major shareholder exits.
Novacyt shares plunge over 40% on Pfizer news, but is this the end?
It's not over for COVID testing specialist Novacyt - despite the crash in its share price, there could still be plenty of demand for its science in 2021.
4D Pharma: NASDAQ listing reflects confidence in future growth
We take a closer look at biotech stock 4D Pharma, a fast moving play in the area of live biotherapeutics that is collaborating with Merck.
Sareum gets the nod for coronavirus research but shares drop
Sareum Holdings has received conditional approval for a UK government grant, but investors seem disappointed with the level of funding.
Moderna shares continue to slide as analysts focus on vaccine delivery obstacles
Moderna shares seem to be facing headwinds in September, prompted by concerns over vaccine delivery and patent filing transparency.
Can Genedrive shares stage a comeback?
Genedrive shares have dropped from their May highs as investors have become impatient for results from its on site speed testing tech for COVID
Novacyt vs Synairgen: how do they stack up?
We check in on two biotech stocks we covered early in the pandemic - how do they stack up and what are they working on now?
Genedrive [LSE:GDR] stock rally has legs
Testing specialist Genedrive has been in the wilderness for 13 years but the coronavirus has given its technology a chance to shine.
Omega Diagnostics shares up on COVID-19 rapid test
Omega Diagnostics has seen a huge surge in its stock price over the last few weeks, not slowed down by the exercise of further employee stock options.
Novacyt shares up over 134% since Feb on testing breakthrough
We follow up on our original note on Anglo-French biotech stock Novacyt, which has been focusing on expanding its coronavirus testing capabilities
AstraZeneca shares head for one year high as investors pile in
AstraZeneca has added 22% to its share price value since 16 March - apart from COVID-19, is there anything else driving investor interest?
Synairgen launches trial of experimental respiratory drug on COVID-19 patients
UK drugs developer has started live trials with coronavirus patients of a treatment already proven with asthma sufferers.
Harvia: a sauna leader with global reach
Our Nordic analyst gets steamed about the Finnish fascination with the sauna and how one sauna stock is taking the world by storm.
German pharmaceutical group Bayer and motor dealership Pendragon
Peter Watson reviews the news to bring you two of his favourite stories each day. Today he talks about German pharmaceutical group Bayer and motor dealership Pendragon
Will results give investors of Indivior shares a shot in the arm?
Indivior shares: With results duenext week, investors will be looking to forecasts for the current financial year, specifically the extent of the hit to sales of Suboxone
A period of sustained growth for AstraZeneca shares?
Given that the company said that it now expects a ‘period of sustained growth for years to come’ there is going to be a lot of pressure on Thursday’s full year results
Shire deal looks like classic pairs trade for investors
Takeda shareholders will be voting on Wednesday on an offer to buy Ireland's Shire in an acquisition that is being…
Shire Pharmaceuticals: Tiki-taka Takeda?
Shares fall almost 4% lower after US group Allergan declares it would not make an offer
Are GSK shares a long term FTSE beater?
GSK shares have outperformed the FTSE 100 since the Great Financial Crisis - is this a share for your ISA?
Reckitt Benckiser shares lacking sparkle under Kapoor regime
The market will be looking for something special from Reckitt Benckiser this week, but we fear it will be sadly disappointed.
Where to put your money before the market crashes
With the last major correction in stocks a decade ago, we are due a market crash as valuations continue to rise
ALK Abello stock on hold after dividends announcement
Danish pharma company upsets shareholders by suspending dividend to invest more in key US market.
Shire Pharmaceuticals stock faces new Roche threat
All eyes are on new Roche treatment as majority of UK brokers call Shire Pharmaceuticals stock a buy
GSK shares take a tumble: buy Pfizer instead?
GSK shares are under pressure as investors lose confidence in the pharma giant's ability to maintain it's dividend yield at current levels
NMC Health shares continue their meteoric rise
The NMC Health share price has risen 98% in just one year. We look at the fundamentals to find out if this performance can continue
NNN Healthcare Office REIT: why healthcare and property make a good match
The healthcare REIT sector is considered to be a solid long term investment, particularly as the need to accommodate an ageing population in the US increases
Growth Stocks: NMC Health [NMC]
Our pursuit of growth stocks has led us to Healthcare provider, NMC Health PLC. Here's why